Genetic and cellular markers in Bipolar Disorders

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day to day tasks and associated with significant comorbidity. The recognition of the significant morbidity and mortality of patients with bipolar disorder, as well as the growing appreciation that a high percentage of patients respond poorly to existing treatments, has made the task of discovering new chemotherapeutic agents, which are both efficacious and have few side effects increasingly more important. Most recent agents introduced into the pharmacopeia for the treatment of bipolar disorder have been anticonvulsants and atypical antipsychotics.

  • Antipsychotic and anticonvulsants
  • Phosphodiesterase activity
  • Glucocorticoid signaling
  • Neurotrophic pathways
  • Cellular lasticity
  • Neuroactive steroids
  • Antiepileptic and mood stabilser
  • Presynaptic Glutamatergic

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